- Authors
- U. Lueken Technische Universität Dresden, Institute of Clinical Psychology and Psychotherapy, Germany
- B. Straube
- I. Reinhardt
- N. I. Maslowski
- H.-U. Wittchen
- A. Ströhle
- A. Wittmann
- B. Pfleiderer
- C. Konrad
- A. Ewert
- C. Uhlmann
- V. Arolt
- A. Jansen
- T. Kircher
- title
- Altered top-down and bottom-up processing of fear conditioning in panic disorder with agoraphobia
- Please use the following URL when quoting:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-390071
- original0000000000000
- Psychological Medicine Erscheinungsort: Cambridge
Verlag: Cambridge University Press
Erscheinungsjahr: 2014
Jahrgang: 44
Heft: 2
Seiten: 381-394
ISSN: 0033-2917
E-ISSN: 1469-8978 - publication_date
- 2014
- Abstract (EN)
- Background: Although several neurophysiological models have been proposed for panic disorder with agoraphobia (PD/AG), there is limited evidence from functional magnetic resonance imaging (fMRI) studies on key neural networks in PD/AG. Fear conditioning has been proposed to represent a central pathway for the development and maintenance of this disorder; however, its neural substrates remain elusive. The present study aimed to investigate the neural correlates of fear conditioning in PD/AG patients. Method: The blood oxygen level-dependent (BOLD) response was measured using fMRI during a fear conditioning task. Indicators of differential conditioning, simple conditioning and safety signal processing were investigated in 60 PD/AG patients and 60 matched healthy controls. Results: Differential conditioning was associated with enhanced activation of the bilateral dorsal inferior frontal gyrus (IFG) whereas simple conditioning and safety signal processing were related to increased midbrain activation in PD/AG patients versus controls. Anxiety sensitivity was associated positively with the magnitude of midbrain activation. Conclusions: The results suggest changes in top-down and bottom-up processes during fear conditioning in PD/AG that can be interpreted within a neural framework of defensive reactions mediating threat through distal (forebrain) versus proximal (midbrain) brain structures. Evidence is accumulating that this network plays a key role in the aetiopathogenesis of panic disorder.
- otherVersion00000
- Link zum Artikel der zuerst in der Zeitschrift 'Psychological Medicine' erschienen ist
DOI: 10.1017/S0033291713000792 - Keywords (DE)
- Agoraphobie, Abwehrreaktion, Angstkonditionierung, fMRT, Frontalkortex, Mittelhirn, Panikstörung
- Keywords (EN)
- Agoraphobia, defensive reaction, fear conditioning, fMRI, frontal cortex, midbrain, panic disorder
- Classification (DDC)
- 610
- Publishing house
- Cambridge University Press, Cambridge
- Project sponsoring
- Ministerium für Bildung und Forschung
ID: 01GV0615
Ministerium für Bildung und ForschungBMBF-Psychotherapie
ID: 01GV0611 - version
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-390071
- Qucosa date of publication
- 11.06.2020
- Document type
- article
- Document language
- English
- licence