- Titel
- An MRI Deep Learning Model Predicts Outcome in Rectal Cancer
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-978250
- Quellenangabe
- Radiology
Erscheinungsjahr: 2023
Jahrgang: 307
Heft: 5
Artikelnummer: 222223 - Erstveröffentlichung
- 2023
- Abstract (EN)
- Background: Deep learning (DL) models can potentially improve prognostication of rectal cancer but have not been systematically assessed. - Purpose: To develop and validate an MRI DL model for predicting survival in patients with rectal cancer based on segmented tumor volumes from pretreatment T2-weighted MRI scans. - Materials and Methods: DL models were trained and validated on retrospectively collected MRI scans of patients with rectal cancer diagnosed between August 2003 and April 2021 at two centers. Patients were excluded from the study if there were concurrent malignant neoplasms, prior anticancer treatment, incomplete course of neoadjuvant therapy, or no radical surgery performed. The Harrell C-index was used to determine the best model, which was applied to internal and external test sets. Patients were stratified into high- and low-risk groups based on a fixed cutoff calculated in the training set. A multimodal model was also assessed, which used DL model–computed risk score and pretreatment carcinoembryonic antigen level as input. - Results: The training set included 507 patients (median age, 56 years [IQR, 46–64 years]; 355 men). In the validation set (n = 218; median age, 55 years [IQR, 47–63 years]; 144 men), the best algorithm reached a C-index of 0.82 for overall survival. The best model reached hazard ratios of 3.0 (95% CI: 1.0, 9.0) in the high-risk group in the internal test set (n = 112; median age, 60 years [IQR, 52–70 years]; 76 men) and 2.3 (95% CI: 1.0, 5.4) in the external test set (n = 58; median age, 57 years [IQR, 50–67 years]; 38 men). The multimodal model further improved the performance, with a C-index of 0.86 and 0.67 for the validation and external test set, respectively. - Conclusion: A DL model based on preoperative MRI was able to predict survival of patients with rectal cancer. The model could be used as a preoperative risk stratification tool.
- Andere Ausgabe
- Link zum Artikel, der zuerst in der Zeitschrift „Radiology” im Verlag Radiological Society of North America erschienen ist.
DOI: 10.1148/radiol.222223 - Verweis
- Ergänzendes Material ist unter folgendem Link zu finden.
Link: https://pubs.rsna.org/doi/suppl/10.1148/radiol.222223 - Freie Schlagwörter (EN)
- Deep-Learning-Modelle (DL), MRI DL model, Rectal Cancer, tumor volumes, MRI scans
- Klassifikation (DDC)
- 610
- Verlag
- Radiological Society of North America, Oak Brook, Ill.
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-978250
- Veröffentlichungsdatum Qucosa
- 20.04.2026
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY 4.0