- Titel
- Alcohol‑induced deficits in reactive control of response selection and inhibition are counteracted by a seemingly paradox increase in proactive control
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-962831
- Quellenangabe
- Scientific reports
Erscheinungsjahr: 2023
Jahrgang: 13
E-ISSN: 2045-2322
Artikelnummer: 1097 - Erstveröffentlichung
- 2023
- Abstract (EN)
- High-dose alcohol intoxication reduces cognitive control, including inhibition. Although inhibition deficits may contribute to the behavioral deficits commonly observed in alcohol use disorder (AUD), many questions about potentially modulating factors have remained unanswered. We examined the effects of experimentally induced high-dose alcohol intoxication (~ 1.1 ‰) on the interplay between controlled vs. automatic response selection and inhibition in healthy young men. A holistic EEG-based theta activity analysis that considered both reactive control during task performance and preceding proactive control processes was run. It revealed a previously unknown seesaw relationship, with decreased reactive control, but paradoxically increased proactive control. Most importantly, alcohol-induced increases in proactive occipital theta band power were associated with reductions in negative alcohol effects on reactive control processes associated with decreased activity in the SMA and medial frontal cortex. Our findings demonstrate that research should not solely focus on immediate effects during task performance. Aside from differential neurobiochemical and neuroanatomical effects of alcohol, it is also conceivable that proactive control may have been recruited in a (secondary) response to compensate for alcohol-induced impairments in reactive control. Against this background, it could be promising to investigate changes in such compensatory mechanisms in pronounced alcohol-associated inhibition deficits, like in AUD patients.
- Andere Ausgabe
- Link zum Artikel, der zuerst in der Zeitschrift „Scientific reports” im Verlag Springer Nature erschienen ist.
DOI: 10.1038/s41598-023-28012-5 - Verweis
- Ergänzendes Material ist unter folgendem Link zu finden.
Link: https://www.nature.com/articles/s41598-023-28012-5#Sec13 - Freie Schlagwörter (EN)
- Cognitive neuroscience, Human behaviour, Neuroscience
- Klassifikation (DDC)
- 500
- 600
- Verlag
- Springer Nature, [London]
- Förder- / Projektangaben
- Deutsche Forschungsgemeinschaft (DFG)
SFB 265 - Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-962831
- Veröffentlichungsdatum Qucosa
- 07.11.2025
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY 4.0