- Titel
- HIF and MYC signaling in adrenal neoplasms of the neural crest
- Untertitel
- implications for pediatrics
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-945071
- Quellenangabe
- Frontiers in endocrinology
Erscheinungsjahr: 2023
Jahrgang: 14
E-ISSN: 1664-2392
Artikelnummer: 1022192 - Erstveröffentlichung
- 2023
- Abstract (EN)
- Pediatric neural crest-derived adrenal neoplasms include neuroblastoma and pheochromocytoma. Both entities are associated with a high degree of clinical heterogeneity, varying from spontaneous regression to malignant disease with poor outcome. Increased expression and stabilization of HIF2α appears to contribute to a more aggressive and undifferentiated phenotype in both adrenal neoplasms, whereas MYCN amplification is a valuable prognostic marker in neuroblastoma. The present review focuses on HIF- and MYC signaling in both neoplasms and discusses the interaction of associated pathways during neural crest and adrenal development as well as potential consequences on tumorigenesis. Emerging single-cell methods together with epigenetic and transcriptomic analyses provide further insights into the importance of a tight regulation of HIF and MYC signaling pathways during adrenal development and tumorigenesis. In this context, increased attention to HIF-MYC/MAX interactions may also provide new therapeutic options for these pediatric adrenal neoplasms.
- Andere Ausgabe
- Link zum Artikel, der zuerst in der Zeitschrift „Frontiers in Endocrinology” im Verlag Frontiers erschienen ist.
DOI: 10.3389/fendo.2023.1022192 - Freie Schlagwörter (EN)
- pheochromocytoma, neuroblastoma, catecholamines, sympathoadrenal cell lineage, hypoxia
- Klassifikation (DDC)
- 610
- Verlag
- Frontiers, Lausanne
- Förder- / Projektangaben
- Deutsche Forschungsgemeinschaft (DFG)
CRC/Transregio 205
Die Nebenniere: Zentrales Relais in Gesundheit und Krankheit
(TRR 205)
ID: 314061271 - Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-945071
- Veröffentlichungsdatum Qucosa
- 15.04.2025
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY 4.0