- Titel
- Analysis of the Role of Stellate Cell VCAM-1 in NASH Models in Mice
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-938824
- Quellenangabe
- International journal of molecular sciences
Erscheinungsjahr: 2023
Jahrgang: 24
Heft: 5
ISSN: 1661-6596
E-ISSN: 1422-0067
Artikelnummer: 4813 - Erstveröffentlichung
- 2023
- Abstract (EN)
- Non-alcoholic fatty liver disease (NAFLD) can progress to non-alcoholic steatohepatitis (NASH), characterized by inflammation and fibrosis. Fibrosis is mediated by hepatic stellate cells (HSC) and their differentiation into activated myofibroblasts; the latter process is also promoted by inflammation. Here we studied the role of the pro-inflammatory adhesion molecule vascular cell adhesion molecule-1 (VCAM-1) in HSCs in NASH. VCAM-1 expression was upregulated in the liver upon NASH induction, and VCAM-1 was found to be present on activated HSCs. We therefore utilized HSC-specific VCAM-1-deficient and appropriate control mice to explore the role of VCAM-1 on HSCs in NASH. However, HSC-specific VCAM-1-deficient mice, as compared to control mice, did not show a difference with regards to steatosis, inflammation and fibrosis in two different models of NASH. Hence, VCAM-1 on HSCs is dispensable for NASH development and progression in mice.
- Andere Ausgabe
- Link zum Artikel, der zuerst in der Zeitschrift „International journal of molecular sciences” im Verlag MDPI erschienen ist.
DOI: 10.3390/ijms24054813 - Freie Schlagwörter (EN)
- non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hepatic stellate cells (HSCs), vascular cell adhesion molecule 1 (VCAM-1)
- Klassifikation (DDC)
- 570
- 540
- Verlag
- MDPI, Basel
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-938824
- Veröffentlichungsdatum Qucosa
- 07.11.2025
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY 4.0