- Titel
- Treatment with delgocitinib cream improves itch, pain and other signs and symptoms of chronic hand eczema
- Untertitel
- Results from the Hand Eczema Symptom Diary in a phase IIb randomized clinical trial
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-936181
- Quellenangabe
- Contact dermatitis
Erscheinungsjahr: 2023
Jahrgang: 89
Heft: 1
Seiten: 46-53
E-ISSN: 1600-0536 - Erstveröffentlichung
- 2023
- Abstract (EN)
- Background: Measuring patient-reported outcomes is crucial to fully capture the burden of chronic hand eczema (CHE). - Objectives: To assess the effect of delgocitinib cream on itch, pain and nine additional key signs and symptoms reported by patients with CHE using the Hand Eczema Symptom Diary (HESD). - Methods: In a double-blind, phase IIb dose-ranging trial (NCT03683719), 258 adults with mild to severe CHE were randomized to delgocitinib cream 1, 3, 8 or 20 mg/g or cream vehicle twice daily for 16 weeks. Patients assessed 11 signs and symptoms of CHE daily through the HESD using an 11-point numeric rating scale; this was an exploratory endpoint. - Results: Delgocitinib cream 20 mg/g was associated with an early and sustained reduction in itch and pain, along with clinically relevant reductions of ≥4 points from baseline to Week 16 in 48.4% and 63.6% of patients, respectively (17.9% and 5.9% with cream vehicle). There were improvements versus cream vehicle in all assessed CHE signs and symptoms (20 mg/g, p < 0.05). - Conclusions: Delgocitinib cream reduced itch, pain and other signs and symptoms in patients with CHE. This data correlated with clinician-reported outcomes, indicating that the HESD may be a useful assessment tool for CHE management.
- Andere Ausgabe
- Link zum Artikel, der zuerst in der Zeitschrift „Contact dermatitis” im Wiley-Blackwell Verlag erschienen ist.
DOI: 10.1111/cod.14303 - Freie Schlagwörter (DE)
- chronisches Handekzem, Juckreiz, Beruf, Schmerzen, PRO
- Freie Schlagwörter (EN)
- chronic hand eczema, itch, occupational, pain, PRO
- Klassifikation (DDC)
- 610
- Verlag
- Wiley-Blackwell, Oxford [u. a.]
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-936181
- Veröffentlichungsdatum Qucosa
- 04.10.2024
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY 4.0