- Titel
- Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-916083
- Quellenangabe
- International journal of molecular sciences
Erscheinungsjahr: 2022
Jahrgang: 23
Heft: 19
E-ISSN: 1422-0067
Artikelnummer: 11902 - Erstveröffentlichung
- 2022
- Abstract (EN)
- The contribution of nitric oxide synthases (NOSs) to the pathophysiology of several neuropsychiatric disorders is recognized, but the role of their regulators, dimethylarginine dimethylaminohydrolases (DDAHs), is less understood. This study’s objective was to estimate DDAH1 and DDAH2 associations with biological processes implicated in major psychiatric disorders using publicly accessible expression databases. Since co-expressed genes are more likely to be involved in the same biologic processes, we investigated co-expression patterns with DDAH1 and DDAH2 in the dorsolateral prefrontal cortex in psychiatric patients and control subjects. There were no significant differences in DDAH1 and DDAH2 expression levels in schizophrenia or bipolar disorder patients compared to controls. Meanwhile, the data suggest that in patients, DDAH1 and DDHA2 undergo a functional shift mirrored in changes in co-expressed gene patterns. This disarrangement appears in the loss of expression level correlations between DDAH1 or DDAH2 and genes associated with psychiatric disorders and reduced functional similarity of DDAH1 or DDAH2 co-expressed genes in the patient groups. Our findings evidence the possible involvement of DDAH1 and DDAH2 in neuropsychiatric disorder development, but the underlying mechanisms need experimental validation.
- Andere Ausgabe
- Link zum Artikel, der zuerst in „International journal of molecular sciences” erschienen ist.
DOI: 10.3390/ijms231911902 - Verweis
- Ergänzendes Material ist unter folgendem Link zu finden.
Link: https://www.mdpi.com/1422-0067/23/19/11902#app1-ijms-23-11902 - Freie Schlagwörter (DE)
- DDAH1, DDAH2, bipolare Störung, Schizophrenie
- Freie Schlagwörter (EN)
- DDAH1, DDAH2, bipolar disorder, schizophrenia
- Klassifikation (DDC)
- 570
- 540
- Verlag
- Molecular Diversity Preservation International (MDPI), Basel
- Förder- / Projektangaben
- Deutsche Forschungsgemeinschaft (DFG)
ID: IRTG 2773/1 - Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-916083
- Veröffentlichungsdatum Qucosa
- 06.06.2024
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY 4.0