- Titel
- Induction of vascular endothelial growth factor-A165a in human retinal and endothelial cells in response to glyoxal
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-914772
- Quellenangabe
- Therapeutic apheresis and dialysis
Erscheinungsjahr: 2022
Jahrgang: 26
Heft: S1: Supplement: „Proceedings of the 1st virtual joint conference of the International Society for Apheresis and the European Group ‐ International Society for Apheresis, 17‐20 March 2021”
Seiten: 29-34
E-ISSN: 1744-9987 - Erstveröffentlichung
- 2022
- Abstract (EN)
- Low-density lipoprotein (LDL) apheresis is effective and safe for patients with diabetes, proteinuria, and dyslipidemia. Diabetes mellitus is accompanied by ocular microvascular complications like retinal neovascularization or diabetic macular edema. These are leading causes of blindness and can be mediated by abnormal vessel growth and increased vascular permeability due to elevated levels of vascular endothelial growth factor (VEGF) in diabetic patients. In this study, we established methods to study the expression of different VEGF isoforms in human retinal and endothelial cells. The VEGF-A165a isoform is much higher expressed in retinal cells, compared to endothelial cells. Stimulation with glyoxal as a model of oxidative stress under diabetic conditions lead to a pronounced induction of VEGF-A165a in human retinal and endothelial cells. These data suggest that diabetes and oxidative stress induce VEGF-A isoforms which could be relevant in regulating the ingrowths of novel blood vessels into the retina in diabetic patients.
- Andere Ausgabe
- Link zum Artikel der zuerst in der Zeitschrift „Therapeutic apheresis and dialysis” bei Wiley erschienen ist
DOI: 10.1111/1744-9987.13803 - Freie Schlagwörter (DE)
- Diabetes, Endothelzellen, Glyoxal, Netzhautzellen, VEGF-A
- Freie Schlagwörter (EN)
- diabetes, endothelial cells, glyoxal, retinal cells, VEGF-A
- Klassifikation (DDC)
- 610
- Verlag
- Wiley, Hoboken
- Förder- / Projektangaben
- Gemeinsame Wissenschaftskonferenz (GWK)
Zukunftskonzept, Maßnahme „Förderung der Besten“ - Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-914772
- Veröffentlichungsdatum Qucosa
- 22.05.2024
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY-NC 4.0