- Titel
- Perturbations of mesenchymal stromal cells after allogeneic hematopoietic cell transplantation predispose for bone marrow graft- versus-host-disease
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-914112
- Quellenangabe
- Frontiers in immunology
Erscheinungsjahr: 2022
Jahrgang: 13
E-ISSN: 1664-3224
Artikelnummer: 1005554 - Erstveröffentlichung
- 2022
- Abstract (EN)
- Functional impairment of the bone marrow (BM) niche has been suggested as a major reason for prolonged cytopenia and secondary graft failure after allogeneic hematopoietic cell transplantation (alloHCT). Because mesenchymal stromal cells (MSCs) serve as multipotent progenitors for several niche components in the BM, they might play a key role in this process. We used collagenase digested trephine biopsies to directly quantify MSCs in 73 patients before (n = 18) and/or after alloHCT (n = 65). For the first time, we demonstrate that acute graft-versus-host disease (aGvHD, n = 39) is associated with a significant decrease in MSC numbers. MSC reduction can be observed even before the clinical onset of aGvHD (n = 10). Assessing MSCs instantly after biopsy collection revealed phenotypic and functional differences depending on the occurrence of aGvHD. These differences vanished during ex vivo expansion. The MSC endotypes observed revealed an enhanced population of donor-derived classical dendritic cells type 1 and alloreactive T cells as the causing agent for compartmental inflammation and MSC damage before clinical onset of aGvHD was ascertained. In conclusion, MSCs endotypes may constitute a predisposing conductor of alloreactivity after alloHCT preceding the clinical diagnosis of aGvHD.
- Andere Ausgabe
- Link zum Artikel der zuerst in der Zeitschrift „Frontiers in immunology” bei Frontiers Media erschienen ist
DOI: 10.3389/fimmu.2022.1005554 - Freie Schlagwörter (DE)
- mesenchymale Stromazellen, allogene hämatopoetische Stammzelltransplantation, Transplantat-gegen-Wirt-Krankheit, Alloreaktivität, Knochenmark-Nische
- Freie Schlagwörter (EN)
- mesenchymal stromal cells, allogeneic hematopoietic stem cell transplantation, graft-versus-host-disease, alloreactivity, bone marrow niche
- Klassifikation (DDC)
- 610
- Verlag
- Frontiers Media, Lausanne
- Förder- / Projektangaben
- University Hospital Carl Gustav Carus Dresden (DFG)
ID: EK 108032016 - Deutsche Forschungsgemeinschaft (DFG)
SPP 2127: Gen- und Zellbasierte Therapien für die Behandlung neuroretinaler Degeneration
ID: 399422891 - Deutsche Forschungsgemeinschaft ID: SU 1360/1-1
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-914112
- Veröffentlichungsdatum Qucosa
- 30.05.2024
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY 4.0