- Titel
- The need for a strategic therapeutic approach
- Untertitel
- multiple sclerosis in check
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-910763
- Quellenangabe
- Therapeutic advances in chronic disease
Erscheinungsjahr: 2022
Jahrgang: 13
Seiten: 1-15
E-ISSN: 2040-6231 - Erstveröffentlichung
- 2022
- Abstract (EN)
- Multiple sclerosis (MS) is the most common chronic autoimmune neurological disease. Its therapeutic management has drastically evolved in the recent years with the development of specific disease-modifying therapies (DMTs). Together with the established injectables, oral and intravenous alternatives are now available for MS patients with significant benefits to modulate the disease course. Certain drugs present with a higher efficacy than the others, profiles and frequencies of adverse events differentiate as well. Thus due to the several and different treatment alternatives, the therapeutic approach adopted by neurologists requires a tactical focus for a targeted, timed, and meaningful treatment decision. An integration of rational and emotional control with proper communication skills is necessary for shared decision-making with patients. In this perspective paper, we reinforce the necessary concept of strategic MS treatment approach using all available therapies based on scientific evidence and current experience. We apply a didactic analogy to the strategic game chess. The opening with oriented attack (i.e. already in early disease stages as clinical isolated syndrome), a correct choice of chess pieces to move (i.e. among the several DMTs), a re-assessment reaction to different scenarios (e.g. sustained disease activity, adverse events, and family planning) and the advantage of real-world data are discussed to try the best approach to ultimately successfully approach the best personalized MS treatment.
- Andere Ausgabe
- Link zum Artikel, der zuerst in „Therapeutic advances in chronic disease” erschienen ist
DOI: 10.1177/20406223211063032 - Verweis
- Ergänzendes Material ist unter folgendem Link zu finden.
Link: https://journals.sagepub.com/doi/10.1177/20406223211063032#supplementary-materials - Freie Schlagwörter (DE)
- krankheitsmodifizierende Therapien, DMTs, Multiple Sklerose, Strategie, Behandlung, Schach
- Freie Schlagwörter (EN)
- disease-modifying therapies, DMTs, multiple sclerosis, strategy, treatment, chess
- Klassifikation (DDC)
- 610
- Verlag
- Sage, London
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-910763
- Veröffentlichungsdatum Qucosa
- 06.06.2024
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY 4.0