- Titel
- Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-904116
- Quellenangabe
- Scientific reports
Erscheinungsjahr: 2022
Jahrgang: 12
Seiten: 1-5
E-ISSN: 2045-2322
Artikelnummer: 1446 - Erstveröffentlichung
- 2022
- Abstract (EN)
- Deep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson’s disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage and found no difference between 92 patients with chronic STN-DBS and 57 patients on best medical treatment. Serum NFL transiently increased after DBS surgery whereas the initiation of STN stimulation did not affect NFL levels, suggesting that DBS surgery can be associated with neuronal damage whereas stimulation itself is not.
- Andere Ausgabe
- Link zum Artikel, der zuerst in „Scientific reports” erschienen ist.
DOI: 10.1038/s41598-022-05117-x - Freie Schlagwörter (DE)
- Neurofilament, neuronale Schäden, Tiefe Hirnstimulation (DBS), Parkinson-Krankheit, Stimulation
- Freie Schlagwörter (EN)
- neurofilament, neuronal damage, Deep brain stimulation (DBS), Parkinson’s disease, stimulation
- Klassifikation (DDC)
- 500
- 600
- Verlag
- Macmillan Publishers Limited, part of Springer Nature, [London]
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-904116
- Veröffentlichungsdatum Qucosa
- 04.04.2024
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY 4.0