- Titel
- What’s happening where when SARS-CoV-2 infects
- Untertitel
- are TLR7 and MAFB sufficient to explain patient vulnerability?
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-900051
- Quellenangabe
- Immunity & ageing
Erscheinungsjahr: 2022
Jahrgang: 19
E-ISSN: 1742-4933
Artikelnummer: 6 - Erstveröffentlichung
- 2022
- Abstract (EN)
- The present COVID-19 pandemic has revealed that several characteristics render patients especially prone to developing severe COVID-19 disease, i.e., the male sex, obesity, and old age. An explanation for the observed pattern of vulnerability has been proposed which is based on the concept of low sensitivity of the TLR7-signaling pathway at the time of infection as a common denominator of vulnerable patient groups. We will discuss whether the concept of established TLR-tolerance in macrophages and dendritic cells of the obese and elderly prior to infection can explain not only the vulnerability of these two demographic groups towards development of a severe infection with SARS-CoV-2, but also the observed cytokine response in these vulnerable patients, which is skewed towards pro-inflammatory cytokines with a missing interferon signature.
- Andere Ausgabe
- Link zum Artikel, der zuerst in der Zeitschrift „Immunity & ageing” erschienen ist.
DOI: 10.1186/s12979-022-00262-3 - Freie Schlagwörter (DE)
- COVID-19, SARS-CoV-2, Fettleibigkeit, Alter, TLR-Toleranz, TLR7, MAFB, miR-146a, Makrophagen, plasmazytoide dendritische Zellen
- Freie Schlagwörter (EN)
- COVID-19, SARS-CoV-2, Obesity, Age, TLR-tolerance, TLR7, MAFB, miR-146a, Macrophages, Plasmacytoid dendritic cells
- Klassifikation (DDC)
- 610
- Verlag
- BioMed Central, London
- Förder- / Projektangaben
- German Cancer Aid Fellow Programm Mildred Scheel Early Career Center at the CRTD
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-900051
- Veröffentlichungsdatum Qucosa
- 20.03.2024
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY 4.0