- Titel
- Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-765193
- Quellenangabe
- Proceedings of the National Academy of Sciences of the United States of America
Erscheinungsjahr: 2021
Jahrgang: 118
Heft: 37
ISSN: 0027-8424
E-ISSN: 1091-6490 - Erstveröffentlichung
- 2021
- Abstract (EN)
- The failure of β cells to secrete sufficient amounts of insulin is a key feature of diabetes mellitus. Each β cell secretes only a small amount of insulin upon stimulation in a highly regulated fashion: young insulin is preferentially released, whereas old insulin is mainly degraded within the β cell. How this process is regulated in vivo and likely altered in diabetes is currently unknown. We present here a transgenic pig model that allows the in vivo fluorescent labeling of age-distinct insulin secretory granule pools, hence providing a close-to-life readout of insulin turnover. This will enable the study of alterations in β cell function in an animal model close to humans.
- Andere Ausgabe
- Link zum Artikel, der zuerst in 'Proceedings of the National Academy of Sciences of the United States of America' erschienen ist.
DOI: https://doi.org/10.1073/pnas.2107665118 - Freie Schlagwörter (DE)
- Betazelle, Insulinumsatz, Schweinemodell, Diabetes mellitus
- Freie Schlagwörter (EN)
- beta cell, insulin turnover, pig model, diabetes mellitus
- Klassifikation (DDC)
- 500
- Herausgeber (Institution)
- National Academy of Sciences of the United States of America, Washington D.C.
- Förder- / Projektangaben
- Innovative Medicines Initiative (IMI-JU)
RHAPSODY for precision therapy and prevention of diabetes
(RHAPSODY) - Deutsche Forschungsgemeinschaft (DFG)
Biologie der Xenogenen Zell-, Gewebe- und Organtransplantation von der Grundlagenforschung zur klinischen Anwendung
(SFB/Transregio 127) - Version / Begutachtungsstatus
- angenommene Version / Postprint / Autorenversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-765193
- Veröffentlichungsdatum Qucosa
- 09.11.2021
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY-NC-ND 4.0