- Titel
- The making of insulin in health and disease
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-733975
- Quellenangabe
- Diabetologia
Erscheinungsjahr: 2020
Jahrgang: 63
Heft: 10
Seiten: 1981-1989
E-ISSN: 1432-0428 - Erstveröffentlichung
- 2020
- Abstract (EN)
- The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century. Since then, the availability of insulin has shifted the focus of diabetes treatment from trying to keep patients alive to saving and improving the life of millions. Throughout this time, basic and clinical research has advanced our understanding of insulin synthesis and action, both in healthy and pathological conditions. Yet, multiple aspects of insulin production remain unknown. In this review, we focus on the most recent findings on insulin synthesis, highlighting their relevance in diabetes.
- Andere Ausgabe
- Zuerst erschienen bei Springer Link.
DOI: 10.1007/s00125-020-05192-7 - Freie Schlagwörter (DE)
- Beta-Zellen, Insulinreifung
- Freie Schlagwörter (EN)
- beta cells, insulin maturation
- Klassifikation (DDC)
- 610
- Verlag
- Diabetologia, Berlin/Heidelberg
- Förder- / Projektangaben
- European Commission (BMBF)
H2020 | IMI2-RIA
Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification
(RHAPSODY)
ID: 115881 - European Commission (DFG)
H2020 | IMI2-RIA
Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes
(INNODIA)
ID: 115797 - Bundesministerium für Bildung und Forschung Deutsches Zentrum für Diabetesforschung
(DZD) - Deutsche Forschungsgemeinschaft
- French National Agency for Research
- German-Israeli Foundation
- Swiss State Secretariat for Education‚ Research and Innovation
- European Federation of Pharmaceutical Industries and Associations
- JDRF International
- Helmsley Charitable Trust
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-733975
- Veröffentlichungsdatum Qucosa
- 20.01.2021
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Deutsch
- Lizenz / Rechtehinweis
CC BY 4.0