- Titel
- Primary Tumor Size in Renal Cell Cancer in Relation to the Occurrence of Synchronous Metastatic Disease
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-705518
- Quellenangabe
- Urologia internationalis Erscheinungsort: Basel
Verlag: Karger
Erscheinungsjahr: 2014
Jahrgang: 92
Heft: 4
Seiten: 462-467
ISSN: 0042-1138
E-ISSN: 1423-0399 - Erstveröffentlichung
- 2014
- Abstract (EN)
- Objectives: To investigate the controversially discussed relationship between tumor size and the occurrence of primary synchronous metastatic disease in renal cell cancer (RCC). Patients and Methods: A consecutive RCC cohort of 2,058 patients (150 primary metastatic) who underwent surgery between 1995 and 2010 was investigated. Rates of synchronous metastases were calculated for stratified groups of tumor size. Uni- and multivariate logistic regression models were calculated for the correlation of tumor size with primary metastatic disease. Results: The rate of metastatic disease increased with increasing tumor size. Tumor size was significantly correlated with synchronous metastatic disease (p < 0.001, c-index 0.772), but for RCCs ≤ 4 cm in size no significant correlation was found. Regarding tumors ≤ 5 cm in size, the correlation became significant (p = 0.028, c-index 0.621). A multivariate logistic regression model for the prediction of synchronous metastatic disease including tumor size, age and comorbidity yielded a significant c-index of 0.82 and was used to construct a nomogram. Conclusion: Our data confirm the correlation between tumor size and the rate of synchronous metastatic disease. Small renal tumors <4 cm in size have a low risk of synchronous metastatic disease. The risk becomes significantly associated with tumor size for tumors ≤ 5 cm.
- Andere Ausgabe
- Link zum Artikel der zuerst in der Zeitschrift 'Urologia internationalis' erschienen ist
DOI: 10.1159/000356325 - Freie Schlagwörter (DE)
- Nierenzellkrebs, Tumorgröße, Metastasierung, Staging, Management
- Freie Schlagwörter (EN)
- Renal cell cancer, Tumor size, Metastasis, Staging, Management
- Klassifikation (DDC)
- 610
- Verlag
- Karger, Basel
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-705518
- Veröffentlichungsdatum Qucosa
- 19.05.2020
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
