- Titel
- A biocompatible and functional adhesive aminerich coating based on dopamine polymerization
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-362553
- Quellenangabe
- Journal of Materials Chemistry B Erscheinungsort: London
Verlag: Royal Society of Chemistry
Erscheinungsjahr: 2015
Jahrgang: 3
Heft: 1
Seiten: 72-81
E-ISSN: 1520-6106 - Erstveröffentlichung
- 2015
- Abstract (EN)
- Amine groups physiologically play an important role in regulating the growth behavior of cells and they have technological advantages for the conjugation of biomolecules. In this work, we present a method to deposit a copolymerized coating of dopamine and hexamethylendiamine (HD) (PDAM/HD) rich in amine groups onto a target substrate. This method only consists of a simple dip-coating step of the substrate in an aqueous solution consisting of dopamine and HD. Using the technique of PDAM/HD coating, a high density of amine groups of about 30 nmol cm⁻² was obtained on the target substrate surface. The PDAM/HD coating showed a high cross-linking degree that is robust enough to resist hydrolysis and swelling. As a vascular stent coating, the PDAM/HD presented good adhesion strength to the substrate and resistance to the deformation behavior of compression and expansion of a stent. Meanwhile, the PDAM/HD coating exhibited good biocompatibility and attenuated the tissue response compared with 316L stainless steel (SS). The primary amine groups of the PDAM/HD coating could be used to effectively immobilize biomolecules containing carboxylic groups such as heparin. These data suggested the promising potential of this PDAM/HD coating for application in the surface modification of biomedical devices.
- Andere Ausgabe
- Link zum Artikel, der zuerst in der Zeitschrift 'Journal of Materials Chemistry B' erschienen ist.
DOI: 10.1039/c4tb01236d - Freie Schlagwörter (DE)
- Wachstumsverhalten von Zellen, copolymerisierte Beschichtung, Dopamin, hohe Dichte an Amingruppen, Gewebereaktion
- Freie Schlagwörter (EN)
- growth behavior of cells, copolymerized coating, dopamine, high density of amine groups, tissue response
- Klassifikation (DDC)
- 540
- 530
- Verlag
- Royal Society of Chemistry, London
- Förder- / Projektangaben
- National Natural Science Foundation of China ID: 81271701
- National Natural Science Foundation of China ID: 51173149
- Ministry of Science and Technology of China Key Basic Research Project
ID: 2011CB606204 - Ministry of Science and Technology of China NSFC Key Program
ID: 81330031 - Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-362553
- Veröffentlichungsdatum Qucosa
- 07.01.2020
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
