- Titel
- Polydopamine-mediated long-term elution of the direct thrombin inhibitor bivalirudin from TiO₂ nanotubes for improved vascular biocompatibility
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-362523
- Quellenangabe
- Journal of Materials Chemistry B Erscheinungsort: London
Verlag: Royal Society of Chemistry
Erscheinungsjahr: 2014
Jahrgang: 2
Heft: 39
Seiten: 6767-6778
E-ISSN: 1520-6106 - Erstveröffentlichung
- 2014
- Abstract (EN)
- Thrombosis and restenosis are two major complications associated with current commercial vascular stents. In situ regeneration of a healthy endothelium has been recognized as a promising strategy to address these issues. Numerous strategies have been explored for this goal. However, in most of the cases, they only focused on enhancing endothelial cell growth, ignoring antithrombotic requirements and the competition between smooth muscle cells (SMCs) and endothelial cells (ECs) for their growth. This resulted in non-satisfying clinical results. In this study, we created a multifunctional surface that meets the need of antithrombosis and re-endothelialization. A nanotubular titanium oxide (TiO₂) system has been developed, which elutes the direct thrombin inhibitor, bivalirudin (BVLD); moreover, polydopamine (PDAM) is used to tailor the surface functionality of TiO₂ nanotubes (NTs) for controlling the elution of BVLD. PDAM-functionalized TiO₂ NTs controls the BVLD for more than two months. BVLD eluted from NTs was bioactive and showed a substantial inhibitory effect on thrombin bioactivity, platelet adhesion and activation. In addition, the BVLD-eluting nanotubular TiO₂ system has high selectivity to enhance human umbilical vein endothelial cell (HUVEC) growth, while it inhibits human umbilical artery smooth muscle cell (HUASMC) proliferation. Our design strategy for the BVLD-eluting nanotubular TiO₂ system creates a favorable microenvironment for durable thromboresistance and the promotion of reendothelialization, and thus it is suitable for the long-term treatment of cardiovascular diseases.
- Andere Ausgabe
- Link zum Artikel, der zuerst in der Zeitschrift 'Journal of Materials Chemistry B' erschienen ist.
DOI: 10.1039/c4tb01118j - Freie Schlagwörter (DE)
- Thrombose, Restenose, Gefäßstents, Antithrombose, Reendothelialisierung, nanotubulares Titanoxid (TiO₂) System, langfristige Behandlung
- Freie Schlagwörter (EN)
- Thrombosis, restenosis, vascular stents, antithrombosis, re-endothelialization,nanotubular titanium oxide (TiO₂) system, long-term treatment
- Klassifikation (DDC)
- 540
- 530
- Verlag
- Royal Society of Chemistry, London
- Förder- / Projektangaben
- National Natural Science Foundation of China ID: 81271701
- National Natural Science Foundation of China ID: 51173149
- Ministry of Science and Technology of China Key Basic Research Project
ID: 2011CB606204 - Ministry of Science and Technology of China NSFC Key Program
ID: 81330031 - Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-362523
- Veröffentlichungsdatum Qucosa
- 07.01.2020
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
