- Titel
- Chlorpromazine Combined with Cidofovir for Treatment of a Patient Suffering from Progressive Multifocal Leukoencephalopathy
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa-137531
- Quellenangabe
- Intervirology 2007;50:412–417, ISSN: 0300-5526
- Erstveröffentlichung
- 2008
- Abstract (DE)
- Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
- Abstract (EN)
- We report on a stem cell-transplanted patient with B cell chronic lymphatic leukemia who presented with a subacute onset of focal neurological deficits, gait abnormalities, emotional lability and dementia. Progressive multifocal leukoencephalopathy was diagnosed by magnetic resonance imaging (MRI) of the brain and detection of JC virus genome in the cerebrospinal fluid. Cidofovir and the 5HT2A receptor antagonist chlorpromazine were subsequently administered. A follow-up MRI of the brain 2 weeks after initiation of the antiviral therapy displayed progress of the demyelination, and the patient died 3 months after onset of the neurological symptoms. This report highlights the need for the development of novel and potent strategies for treatment of progressive multifocal leukoencephalopathy.
- Andere Ausgabe
- DOI: 10.1159/000112916
- Volltext des Artikels, der zuerst in der Zeitschrift "Intervirology" des Karger-Verlages erschienen ist.
Link: http://dx.doi.org/10.1159/000112916 - Freie Schlagwörter (DE)
- Chlorpromazin, Progressive multifokale Leukenzephalopathie, PML, JC-Virus, Viruslast, Cidofovir
- Freie Schlagwörter (EN)
- JC viral load, Progressive multifocal leukoencephalopathy, Cidofovir, Chlorpromazine
- Klassifikation (DDC)
- 570, 610
- Klassifikation (RVK)
- WA 15000, XA 10000
- Verlag
- Karger, Basel
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa-137531
- Veröffentlichungsdatum Qucosa
- 18.03.2014
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
