- Titel
- Prediction of incident diabetes mellitus by baseline IGF1 levels
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa-100978
- Quellenangabe
- European Journal of Endocrinology, 2011, Bd. 164, S. 223-229, ISSN: 0804-4643
- Erstveröffentlichung
- 2011
- Abstract (EN)
- Objective: IGF1 is associated with metabolic parameters and involved in glucose metabolism. Low-IGF1 has been implicated in the etiology of glucose intolerance and subjects with pathological causes of either low- or high-IGF1 are at risk of diabetes. We hypothesized that both low- and high-IGF1 levels increase the risk of diabetes and aimed to assess the role of IGF1 in the risk of developing diabetes in a large prospective study. Design: An analysis of two prospective cohort studies, the DETECT study and SHIP. Methods: We measured IGF1 levels in 7777 nondiabetic subjects and assessed incident diabetes mellitus during follow-up. Results: There were 464 cases of incident diabetes during 32 229 person-years (time of follow-up in the DETECT study and SHIP: 4.5 and 5 years respectively). There was no heterogeneity between both studies (P>0.4). The hazard ratios (HRs) of incident diabetes in subjects with IGF1 levels below the 10th or above the 90th age- and sex-specific percentile, compared to subjects with intermediate IGF1 levels, were 1.44 (95% confidence interval (CI) 1.07–1.94) and 1.55 (95% CI 1.06–2.06) respectively, after multiple adjustment. After further adjustment for metabolic parameters, the HR for low-IGF1 became insignificant. Analysis of IGF1 quintiles revealed a U-shaped association of IGF1 with risk of diabetes. Results remained similar after exclusion of patients with onset of new diabetes within 1 year or with borderline glucose or HbA1c levels at baseline. Conclusions: Subjects with low- or high-IGF1 level are at increased risk of developing diabetes.
- Andere Ausgabe
- DOI: 10.1530/EJE-10-0963
- Metadaten und Abstract zu dem Artikel, der zuerst in der Zeitschrift "European Journal of Endocrinology" des BioScientifica-Verlages veröffentlicht wurde.
Link: http://dx.doi.org/10.1530/EJE-10-0963 - Freie Schlagwörter (DE)
- Diabetes, Zuckerkrankheit, Diagnostik, Kohorten-Studie
- Freie Schlagwörter (EN)
- diabetes mellitus, diagnostics, Insulin-like growth factor-I, cohort study, glucose metabolism, DETECT study
- Klassifikation (DDC)
- 610
- Klassifikation (RVK)
- YC 6700
- Verlag
- BioScientifica, Bristol, UK
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa-100978
- Veröffentlichungsdatum Qucosa
- 29.01.2013
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
