- AutorIn
- Katja Beesdo
- James Hartford
- James Russell
- Melissa Spann
- Susan Ball
- Hans-Ulrich Wittchen
- Titel
- The short- and long-term effect of duloxetine on painful physical symptoms in patients with generalized anxiety disorder: Results from three clinical trials
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa-112635
- Quellenangabe
- Journal of Anxiety Disorders, Bd. 23 (2009), Nr. 8, S. 1064–1071, ISSN: 0887-6185
- Erstveröffentlichung
- 2009
- Abstract (EN)
- Generalized anxiety disorder (GAD) is associated with painful physical symptoms (PPS). These post hoc analyses of previous trial data assessed PPS and their response to duloxetine treatment in GAD patients. Studies 1 and 2 (n = 840) were 9- to 10-week efficacy trials; study 3 (n = 887) was a relapse prevention trial comprising a 26-week open-label treatment phase and a 26-week double-blind, placebo-controlled treatment continuation phase. Mean baseline visual analog scale scores (VAS, 0–100; n = 1727) ranged from 26 to 37 for overall pain, headache, back pain, shoulder pain, interference with daily activities, and time in pain while awake. In studies 1 and 2, improvement on all VAS scores was greater in duloxetine-treated than in placebo-treated patients (p ≤ 0.01). In study 3, pain symptoms worsened in responders switched to placebo compared with those maintained on duloxetine (p ≤ 0.02). In conclusion, duloxetine was efficacious in the short- and long-term treatment of PPS, which are common in GAD patients.
- Andere Ausgabe
- DOI: 10.1016/j.janxdis.2009.07.008
- Link zur publizierten Version des Artikels, der in der Zeitschrift Journal of Anxiety Disorders des Elsevier-Verlags erschienen ist.
Link: http://dx.doi.org/10.1016/j.janxdis.2009.07.008 - Freie Schlagwörter (DE)
- Generalisierte Angststörung, Schmerz, Duloxetin, Rückfallprävention, Serotonin-Noradrenalin-Wiederaufnahmehemmer
- Freie Schlagwörter (EN)
- Generalized anxiety disorder, Pain, Duloxetine, Relapse prevention, Serotonin and norepinephrine reuptake Inhibitor
- Klassifikation (DDC)
- 150
- Klassifikation (RVK)
- CU 3100
- Publizierende Institution
- Technische Universität Dresden, Dresden
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa-112635
- Veröffentlichungsdatum Qucosa
- 23.04.2013
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis